The most frequent pairs of ADRs and the drugs responsible were lactic acidosis/metformin (9), metabolic acidosis/sulfamethoxazole and trimethoprim (5), hepatic cytolysis/amoxicillin and beta-lactamase inhibitors (4), depressed level of consciousness/quetiapine (4), and acute kidney injury/methotrexate (4) (see Table S1 in the Supplementary Materials). The gene discussed is LACTB; the disease is metabolic acidosis.