Another combination of the hs-CRP level (≥3 mg/L) and clinical variables (age; sex; hypertension; diabetes mellitus; cigarette smoking; previous history of atherosclerotic cardiovascular disease; hemoglobin; glomerular filtration rate; total cholesterol; left ventricular ejection fraction; and the use of beta-blocker, renin-angiotensin system blocker, and statin) significantly increased prognostic value in predicting MACE (global Chi-square score, from 108 to 126, p < 0.001). The gene discussed is REN; the disease is hypertensive disorder.