Furthermore, since MetS being a low-grade inflammatory state, it is also interesting to study correlation of circulating levels of NLRP3 with other established circulating pro-inflammatory markers, such as tumor necrosis factor α (TNF-α), C-reactive protein (CRP) and interleukins (IL-1β and IL-18) in the same cohort. The gene discussed is IL1B; the disease is metabolic syndrome.