The logistic regression analysis showed that, in females, higher tertiles of NLRP3 levels were associated with higher odds of getting “central obesity”, as well as “low HDL-cholesterol” component of MetS (p-trend 0.02 and 0.04, respectively), and this statistically significant trend persisted even after adjustment with age and BMI. The gene discussed is NLRP3; the disease is Abdominal obesity.