GH1 and Prader-Willi syndrome: To evaluate the combined effect of GH treatment and MD care (GHMDc), we report the prevalence of physical health problems in three groups: adults with PWS who have received GHMDc from childhood to adulthood (GHMDc+ group); those who never received GHMDc (GHMDc− group) and those who have temporarily received GHMDc during childhood, but GHMDc was discontinued before adulthood (GHMDc± group).