Other syndromes related to the development of CVD include lymphedema distichiasis syndrome (LDS), characterized by FOXC2 mutations, cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), affecting the Notch3, Chuvash Polycythemia (VHL mutations), severe congenital neutropenia type 4 (alterations in the G6PC3), and Ehlers-Danlos syndrome (EDS), with defective COL3A1 functioning [118]. Here, NOTCH3 is linked to Ehlers-Danlos syndrome.