The reported variant of the SHL in P. distasonis 33B (RILVELLYLVCSEYL) is able to promote an immune response to the endogenous insB:9–23, and the exposure of female NOD mice to P. distasonis mimic peptide during the gut microbiota maturing precipitated the onset of T1D [49]. This evidence concerns the gene SERHL and type 1 diabetes mellitus.