INS and Autoimmunity: The variants of the preproinsulin signal peptide AWL with sequence MVWGPDPLYV and RQFGPDWIVA were identified in B. fragilis/thetaiotaomicron and C. asparagiforme, and this latter variant was able to activate the 1E6 T cell with higher potency than the ALW sequence highlighting the potential development of autoimmunity by the T- cell cross-reactivity with bacterial derived peptides [49].