Aiming to improve the efficacy of treatment of B cell malignancies in general and of multiple myeloma in particular, we evaluated the impact of crosslinking CD38 receptors on the mechanism and extent of apoptotic induction in four CD38 positive malignant B cells (Daudi, Raji, RPMI 8226, and ANBL-6). The gene discussed is CD38; the disease is AL amyloidosis.