ABCB1 and colorectal adenocarcinoma: A similar observation was previously made for the prenylated flavonoid 8-prenylnaringenin, which was able to reduce Dox accumulation and inhibited ABCB1 activity in Dox-resistant colorectal adenocarcinoma cells (LoVo/Dx), but was not able to affect Dox cytotoxicity [23].