CASP8 and breast adenocarcinoma: Moreover, Yap et al. (2018) reported a strong selective cytotoxicity of serine proteinase in the face of a human breast adenocarcinoma cell line (MCF7) and suggested that the mechanism involves the collaborative effect of both extrinsic and intrinsic cell death mechanisms, in addition to the stimulation of caspase-8 and -9 and inhibition of Bcl-2 [41].