IL1B and ischemia: In the vehicle + TFI group, IL-1β immunoreactivity in the pyramidal cells was dramatically increased (189.3% of the sham group) at 2 days post-ischemia (Figure 4Bb,D), but, at 5 days post-ischemia, IL-1β immunoreactivity in the pyramidal cells was hardly shown (27.9% of the sham group) due to their death (Figure 4Bc,D).