Doxorubicin is easily encapsulated in the chitosan-shelled nanodroplet structure and in DOX-loaded OLNDs, showing, even at low doses, marked effectiveness when administrated both in vitro and in vivo to TUBO cells, in a cloned rat Her2/neu+ cell line established from lobular carcinoma of a BALB-neuT mouse (Figure 4). Here, ERBB2 is linked to breast lobular carcinoma.