ACHE and Alzheimer disease: Considering the above described and with the aim to improve the properties of curcumin and coumarin for the treatment of neurodegenerative diseases such as AD or PD, we have synthesized a series of curcumin–coumarin hybrid analogues (Figure 1) to study their activity as MAO and AChE inhibitors, free radical scavengers as well as their neuroprotective activity against hydrogen peroxide (H2O2).