Neratinib (tyrosine kinase inhibitor) inhibited the action of proteins by binding with adenosine triphosphate (ATP), leading to the inhibition of phosphorylation on EGFR, HER2, HER3, HER4, AKT and ERK inSKBR3 and BT474 cells (HER2+ breast cancer cells). This evidence concerns the gene ERBB3 and breast cancer.