Furthermore, CDK4 overexpression has been observed in uterine cervical and colorectal carcinomas, melanomas, as well as NSCLC, while CDK4 gene amplification has occurred in glioblastomas, uterine cervix cancer, osteosarcomas, rhabdomyosarcomas, and liposarcomas [12,33]. The gene discussed is CDK4; the disease is melanoma.