[Ru(dmp)2(pddppn)](ClO4)2 (pddppn = phenantheno [1,2-b]-1,4-diazabenzo [i] dipyrido [3,2-a:2′,3′-c]phenazine) (Ru33) could also downregulate the expression of BCL-2, BCL-x, BAK, and BIM, while upregulating the expression of BAG-1 and BAD, thus inducing apoptosis of NSCLC A549 cells via an intrinsic ROS-mediated mitochondrial dysfunction pathway [56]. The gene discussed is BCL2; the disease is non-small cell lung carcinoma.