The INK4A-ARF (CDNK2A) locus and DUSP2 (dual specificity phosphatase 2) gene were found to be frequently hypermethylated in MCC tumors, but the viral status in these tumors was not specified, so that a possible role for MCPyV in hypermethylation cannot be determined [93,94]. The gene discussed is CDKN2A; the disease is Merkel cell skin cancer.