DNMT1 and Epstein-Barr virus infection: However, in germinal center B-cells, presumptive progenitors of Hodgkin’s lymphoma, EBV infection resulted in downregulation of DNMT1 and DNMT3B and upregulation of DNMT3A and the authors found that LMP1 is responsible for downregulation of DNMT1, while the mechanism for DNMT3A and DNMT3B remains unknown as ectopic expression of LMP1 or of LMP2A had no effect on DNMT3A and DNMT3B levels [38].