A recent study reported that extracellular vesicles could transmit EBERs from EBV-positive nasopharyngeal carcinoma cells to endothelial cells and promote angiogenesis through upregulation of vascular cell adhesion molecule 1 (VCAM1) expression via TLR3/retinoic acid-inducible gene 1 protein (RIG-1)/MAPK pathway [335]. This evidence concerns the gene PLAAT4 and nasopharyngeal carcinoma.