Examples of cellular lncRNAs upregulated by HBV include highly expressed in HCC (HEIH), UCA1, HOTAIR, HULC, and LINC00152, which all were shown to interact with EZH2 and repress gene expression, thereby promoting proliferation, migration and invasion, cell survival, and tumor growth. The gene discussed is EZH2; the disease is hepatocellular carcinoma.