HMGB1 and chronic obstructive pulmonary disease: The release of DAMPs has already been identified in other models (e.g., chronic obstructive pulmonary disease), where it is well established that cigarette smoke exposure can induce necrotic death in airway epithelial cells, provoking DAMP (HMGB1, AGEs, S100, HSP70, and dsDNA) accumulation in the extracellular space [18,34,35,36].