ENTPD1 and graft versus host disease: Finally, a recent study demonstrated that murine CD150hi Treg cells exhibit significantly higher Entpd1 (CD39) and Nt5e (CD73) mRNA expression than CD150- Tregs and mediate their suppressive effect through adenosine production, reducing histological GVHD and mortality, and promoting HSC expansion in an allogeneic mouse model of GVHD [130].