In addition, MSLN and GDF15 were found to be significantly upregulated (fold change = 12.24 for MSLN and fold change = 14.76 for GDF15) in colorectal cancer tissues, as well as to interact with colorectal-cancer-specific enhancers in colorectal cancer cells (Figure 6C, D). The gene discussed is GDF15; the disease is colorectal cancer.