IL6 and cancer: In colorectal cancer (CRC) cells, IL-6 treatment increases the Snail, Slug, Zeb1, TCF3, Fra-1 and FoxQ1 levels [84,85], while in oesophageal, bladder and pancreatic (PDAC) cancer cell lines, different combinations of Snail, Slug, Zeb1, Zeb2, Twist1 and Twist2 transcription factors have been observed to be activated by IL-6 [87,90,91].