Another study in lung cancer reinforced those results, as it showed, by IHC analysis of the tumour specimens from patients with NSCLC after chemo(radio)therapy, that stromal IL-6 expression correlated with EMP changes in cancer cells (decreased E-cadherin and increased N-cadherin and TGFβ1 staining), suggesting that stromal IL-6 expression was an independent prognostic factor in patients with NSCLC [59]. This evidence concerns the gene CDH2 and cancer.