In oesophageal and breast cancer cells, IL-6 exposure has been shown to promote mesenchymal/fibroblastic morphology, migration and invasion in vitro and in vivo, associated with reduced CD24, KRT19, EpCAM and E-cadherin expression and increased vimentin, N-cadherin and MMP9 levels [57,72,73,74,76,90]. This evidence concerns the gene CDH2 and breast carcinoma.