However, the P70S6K kinase was identified by another group as a partial mediator of IL-6 induced EMP in HNSCC, and it could be activated by any of the JAK/STAT3, PI3K/Akt/mTOR and MAPK/ERK pathways downstream of IL-6 signalling [46]. Here, AKT1 is linked to head and neck squamous cell carcinoma.