KEAP1 and Parkinson disease: Supporting this notion of impaired redox homeostasis, several immunohistochemical studies have shown aberrant localization of redox regulating molecules in association with LRP in PD SN, including nuclear factor erythroid 2-related factor 2 (NRF2/Nrf2) [186,187], NRF2 inhibitor Kelch-like ECH-associated protein 1 (Keap1) [188], anti-oxidant heme oxygenase (HO-1) [189] and anti-xenobiotic NAD(P)H quinone dehydrogenase 1 (NQO1) [190].