It is worth considering that the paucity of LRP (inclusions containing fibrillar α-syn, which is ubiquinated [114]) in these subsets of PD cases does not rule out the existence of oligomeric α-syn in the brain, since α-syn oligomers have been reported in the cerebrospinal fluid of individuals who carry LRRK2 mutations, either with a PD diagnosis [252] or in neurologically normal volunteers [253]. The gene discussed is LRRK2; the disease is Parkinson disease.