Specific mutations in the genes including signal transducer and activator of transcription 1 (STAT1), NF-κB essential modulator (NEMO), interferon regulatory factor 8 (IRF8), GATA binding protein 2 (GATA2), and cytochrome B-245 beta chain (CYBB) have been shown to predispose individuals to mycobacterial infections, including TB [46]. This evidence concerns the gene IRF8 and tuberculosis.