Additionally, patients with low NUCB2/NESF-1 mRNA levels had significantly longer biochemical recurrence-free survival (BCR-free—the survival time of a person with prostate cancer during which a biochemical marker—PSA does not rise or rises very little) time after radical prostatectomy compared to patients with high NUCB2/NESF-1 mRNA levels. This evidence concerns the gene KLK3 and Familial prostate cancer.