Correspondingly, the human assessment explicated the serum PRSS8 levels as concomitant major effectors in the development of T2DM, atherosclerosis, and cardiovascular events, and as a putative biomarker for all these evidences might aid in understanding and mediating the regulatory mechanisms of PRSS8 overexpression over glucose and lipid metabolism, as well as excessive hepatic fat storage. Here, PRSS8 is linked to atherosclerosis.