Activation of gut microbiota and TLR4 contributes to the development of cancer in chronically damaged livers.Intestinal microbiota and TLR4 contribute to promotion of HCC, proliferation of cancer, expression of hepatomitogen epiregulin and prevention of apoptosis.In the late stages of liver cancer, limited enteric sterilization reduced hepatocellular carcinoma. Here, TLR4 is linked to liver cancer.