After LPS injection, only the bile duct ligation group progressed to the pre-coma stage.TNF-α and IL-6 levels were significantly increased in LPS-treated animals.LPS injection in a cirrhosis model induces coma due to synergistic effects of hyperammonemia and inflammatory response. It also exacerbates cytotoxic edema. The gene discussed is TNF; the disease is Hyperammonemia.