PPARγ upregulates proteins associated with lipid uptake, TAG storage, and the formation of lipid droplets, such as FABP4, fat-specific protein 27 (FSP27)/Cidec, CD36, monacylglycerol O-acyltransferase 1, and perilipin 2; then PPARγ hepatic expression promotes steatosis. The gene discussed is PPARG; the disease is steatosis.