Serum exosomes expressing high levels of miR-155 following LPS-induced ALI could promote M1 polarization and pro-inflammatory responses in macrophages by suppressing Src homology 2 domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) and suppressor of cytokine signaling 1 (SOCS1) [118]. Here, SOCS1 is linked to acute respiratory distress syndrome.