In a recent study probing the role of triggering receptor expressed in myeloid cells 2 (TREM2)-expressing Kupffer cells (KCs; liver resident macrophages) in regulating lipid dysmetabolism in non-alcoholic fatty liver disease (NAFLD), Hou et al. showed that loss of TREM2 triggered release of KC exosomes which induced mitochondrial dysfunction in hepatocytes through transfer of miRNAs and worsened sepsis mortality in an NAFLD mice model [100]. This evidence concerns the gene TREM2 and metabolic dysfunction-associated steatotic liver disease.