Da Silva et al. show that drug-induced suppression of endoplasmic reticulum (ER) stress and Toll-like receptor (TLR) downstream signaling (including JNK and NF-κB activation) prevented both hyperglycemia and hypoglycemia in septic rats by improving insulin signaling and restoring hepatic G6Pase level, respectively [62]. Here, G6PC1 is linked to Hypoglycemia.