HIPK2 and ischemic cardiomyopathy: In particular, the involvement of HIPK2 in heart pathophysiology is suggested by the evidence that a reduction of HIPK2 in cardiomyocytes leads to cardiac dysfunction in mice and that cardiac HIPK2 expression is significantly reduced in human end-stage ischemic cardiomyopathy, in comparison with non-failing myocardium [23].