On the contrary, an alternative approach involves the utility of miRNA modulation to enhance sensitivity to current conventional therapeutic strategies; Miller at al. illustrate the role of miR-221/miR-222 overexpression in inducing tamoxifen resistance in HER2/neu-positive 4-hydroxytamoxifen-resistant (OHTR) breast cancer cell lines [55]. Here, ERBB2 is linked to breast carcinoma.