Gliomagenesis, as a multi-component process that promotes the development of gliomas, involves amplification and deletion or mutation of several genes, including the epidermal growth factor receptor (EGFR), tumor protein 53 (TP53), phosphate and tensin homolog (PTEN), and isocitrate dehydrogenase (IDH), among others [23]. The gene discussed is IDH1; the disease is central nervous system cancer.