CLOCK and cancer: In addition, it must be considered that the biological clock of the whole organism drives the circadian rhythms in the immune system required to attack the tumor, in the cellular metabolism and bioenergetics, in the drug pharmacokinetics and pharmacodynamics, and in the detoxification mechanisms after chemotherapy, among many other time-controlled aspects, that somehow temporally regulate the pathophysiological state and susceptibility of individuals once they are confronted with a disease such as cancer.