As shown in Figure 4, pretreatment with high phenolic sorghum extracts weakened the IGF-1-stimulated phosphorylation of AKT in three human colon cancer cells, indicating that growth factor/receptors/PI3K/AKT pathways could be an efficient target for cancer prevention using high-phenolic sorghum bran. The gene discussed is IGF1; the disease is colonic neoplasm.