Since we observed a downregulation of β-catenin only in invasive (metastatic) SW480 and HCT-116 cells (Figure 3) and the tumor produced from APC Min/+ mice is a benign adenoma, β-catenin may be a target of sorghum bran extracts only for invasive and metastatic cancer, but not in benign polyps. The gene discussed is APC; the disease is metastatic malignant neoplasm.