To investigate whether sorghum bran extracts possess inhibitory activity against the growth factor-induced PI3K/AKT signaling pathway, we pretreated human colon cancer cells with sorghum bran extracts (HP, SC and Sumac), followed by co-treated with IGF-1, using LY294002 (a selective inhibitor of PI3K) as a positive control. This evidence concerns the gene IGF1 and malignant colon neoplasm.