CDKN2A and neoplasm: The most frequent in MPM pathogenesis are genetic mutations in tumor suppressor genes (including neurofibromin 2 (NF2, merlin), cyclin-dependent kinase inhibitor 2A (CDKN2A), which shares a locus for both p16/INK4 and p14/ARF, and BRCA-associated protein-1 (BAP-1).