Biallelic rare variants in proteins critical for the production of melanin (e.g., TYR) or in pH regulation of the melanosome (e.g., OCA2 and SLC45A2) lead to a significant reduction in melanin pigmentation in the skin, eyes, and hair and give rise to oculocutaneous albinism (OCA) (OCA1, OCA2, and OCA4, respectively). This evidence concerns the gene OCA2 and oculocutaneous albinism.