It has been established that mammalian cells (including both neurons and glia) can accumulate lipid droplets in pathological conditions and in modeling various neurodegenerative disorders, such as Huntington’s and Alzheimer’s disease [128,129,130,131,132], as well as HSP [133,134,135,136]. The gene discussed is HSP90B2P; the disease is early-onset autosomal dominant Alzheimer disease.