Although similar specificity and affinity as 4H84 mAbs was claimed, the HLA-G-positive sample rate showed a tendency to be higher compared to 4H84 mAbs with similar HLA-G quantification methods (Ye et al. vs. Zeestraten et al. in CRC [24,30]; Lin et al. vs. Yie et al. in ESCC [32,33]; Du et al. vs. Yie et al. in GC [35,40]; Lin et al. vs. Yie et al. in NSCLC [43,45]). This evidence concerns the gene HLA-G and esophageal squamous cell carcinoma.