CGP 46381 significantly reversed the antimelanogenic effect of GABA in α-MSH-treated B16F10 melanoma cells (from 121.2% ± 8.4% to 268.8% ± 5.1% of extracellular (Figure 6A) and from 119.9% ± 18.2% to 191.8% ± 7.9% of intracellular melanin content (Figure 6B)). This evidence concerns the gene STAMBP and melanoma.