Based on the data presented, we suggest that Netrin-1 could participate in the control of neovascularization processes in GBM through the regulation of C-MYC expression by activating three possible signaling axes: NTN1/NEO1/FAK/Integrinβ1 axis, NTN1/UNC5B/NEO1/Gsk3α/β axis, and/or the NTN1/UNC5A/NF-κB axis (Figure 3). Here, MYC is linked to glioblastoma.