CYP2E1 and metabolic dysfunction-associated steatohepatitis: The connection between CYP2E1 and NASH was first suggested by Weltman et al., in 1996, where elevated levels of CYP2E1 were observed in steatosis and NASH patients, particularly in the centrilobular region [109] corresponding to the site of maximal hepatocellular injury in NASH [41,110].