CD8A and adenocarcinoma: Furthermore, when the proportions of proliferation (Ki-67), apoptosis (single strand-DNA, ss-DNA), and CD8+ T cell infiltration in adenocarcinoma were examined, there was no significant change in proliferation among any of the groups, but apoptosis and CD8+ T cell infiltration were increased in group 3 (BCM+TOP) in comparison with those in group 1 and 2 (Figure 4E,F).