CP and aceruloplasminemia: Despite the fact that the coding sequence of human CP has been known since 1986 [24], a survey of the literature shows that, apart from our previous work on aceruloplasminemia mutants [20,25], only one paper published in 2001 reports expression and purification of limited amounts of recombinant human CP, using the yeast Pichia pastoris as host [26].