GNRH1 and cyclic hematopoiesis: Conversely, in times of starvation when fat reserves are low, with consequent reduction in the serum levels of leptin (hypoleptinaemia), there is activation of agouti-related peptide neurons that in turn suppress activity within kisspeptin cells with consequent suppression of GnRH release, reproductive function and leads to the development of CH [71].