LEP and obesity due to melanocortin 4 receptor deficiency: Examples of such gene mutations include those within SOX10 (KS in the context of Waardenburg-Shah syndrome) [46], HESX1 (KS in the context of pituitary hormone deficiency and septo-optic dysplasia) [47], NROB1 (ICH in the context of congenital adrenal dysplasia) [45] and LEP (ICH in the context of obesity) [45].