TARDBP and amyotrophic lateral sclerosis: In rodent primary cortical neurons, the TDP-43-positive ribonucleoprotein granules exhibited liquid-like properties and mediated several cellular functions [68]; however, ALS-linked mutations, such as G298S and M337V, significantly decreased their motility and increased their viscosity, which led to the impairment of their normal function to transport granules (Figure 1) [68].