TARDBP and amyotrophic lateral sclerosis: As a pathological hallmark in ALS, cytoplasmic TDP-43 inclusions were mainly described as amorphous aggregates that were thioflavin-negative; however, a subset of diagnostic skein-like inclusions were thioflavin-positive, consistent with the ability of TDP-43 to deposit into amyloid fibrils [99,100,101].