NLRP3 and Alzheimer disease: The astrocyte reaction in AD involves several signaling pathways: the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3), the calcineurin/nuclear factor of activated T cells (calcineurin/NFAT), the nuclear factor-kB/nod-like receptor family pyrin domain containing 3(NFκB/NLRP3), the mitogen-activated protein kinase (MAPK), and the P2Y1 purinoreceptor (P2Y1R) pathways (Figure 1, panel B) [211].