DMBT1, which was upregulated by IL-22Fc and was neutral to the presence of IL-1β, is also involved in IBD, as shown by [23] where IL-22 and DMBT1 transcripts were upregulated in mucosal tissues from UC patients, as well as by Deigelmann et al. [24], who identified several DMBT1 variants associated with CD susceptibility. Here, IL22 is linked to inflammatory bowel disease.