IL22 and malignant colon neoplasm: The available human IL-22 data include those from the treatment of a human colon cancer cell line, SW403, with IL-22, which induced the upregulation of REG1A and S100A9 (anti-microbial genes related to those observed in the mouse), SOCS3 (a common STAT3-driven gene), and DMBT1 (deleted in malignant brain tumors 1) [23], an antibacterial pattern recognition and scavenger receptor also shown to be upregulated by IL-22 in the human HT-29 and DLD-1 cell lines [24].