FUS and amyotrophic lateral sclerosis: More recently, among 1232 FDA-approved drugs screened on ALS hiPSC-MN, ropinirole, a dopamine D2 receptor (D2R) agonist, was found to rescue ALS-related pathologies such as FUS/TDP-43 mislocalization, stress granule formation, neurite retraction, and MN degeneration.