PPP3CA and cardiac hypertrophy: PPP3CA, which encodes a catalytic subunit of calcineurin, is regulated by miR-30 family members in podocytes and cardiomyocytes [17]; in this regard, estrogen action on PPP3CA expression has already been reported, since estradiol exposition decreases PPP3CA expression and reduces cardiomyocyte hypertrophy [20], which could explain the sex differences observed in cardiac hypertrophy [21].