SLC8A3 and neurodegenerative disease: This finding is in line with data previously reported [20], showing that NCX3, apart its localization at plasma membrane level, is also localized on the outer mitochondrial membrane and promotes mitochondrial calcium efflux in physiological and pathological conditions, thus playing a pivotal role in the maintenance of intracellular Na+ and Ca2+ homeostasis not only in brain ischemia but also in neurodegenerative diseases [17,36,37,45,46,47,48,49].