CCL2 and cancer: This last possibility is quite reasonable for the following reasons: we have shown before that LN-MSC increased the secretion of pro-inflammatory cytokines (mainly IL-6, IL8, and CCL2) [30]; also, others and we have shown, in different cancer models, that this type of paracrine stimulation reinforces and preserves a senescent/pro-inflammatory microenvironment that promotes tumorigenesis [54,55,56,57].