While analysis of the list of differentially expressed genes between Vadadustat preconditioning and control cells using the KEGG database indicated upregulation of 9 genes associated with renal cell carcinoma and 10 genes associated with colorectal cancer, this was not surprising as it was already known that the HIF-1 pathway is upregulated in these two types of cancer [36,37]. The gene discussed is HIF1A; the disease is cancer.