MAPT and Alzheimer disease: Interestingly, higher levels of Aβ1-42, total tau, p-T181-tau, and p-S396-tau in circulating EVs have been found in Alzheimer’s disease (AD) compared to controls and, moreover, elevated levels of EV Aβ1-42, p-T181-tau and p-S396-tau were detected in a preclinical group, which could predict disease development 10 years before clinical diagnosis [85].